Single-Camera Multiparametric Imaging in Cardiac Electrophysiology

Magazine
  • 2012
  • July
Wednesday, June 5, 2013 - 11:00

The field of cardiac electrophysiological imaging has advanced tremendously in the past three decades with developments in fluorescent dyes, photodetectors, optical filters, illumination sources, computers and electronics. Here, we describe a scalable multiparametric imaging system and its application to low-light 2D tissue preparations: thin ventricular tissue slices and human iPS cell-derived cardiomyocyte monolayers. The three key electrophysiological parameters measured were transmembrane voltage, intracellular calcium concentration and excitation wave propagation. Such approaches may soon lead to high-throughput drug testing and patient-specific investigation of cardiac diseases.

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