Volume 20, Issue 5 (September 2006)

Batten disease, or neuronal ceroid lipofuscinosis (NCL), is the collective name of a group of inherited, fatal storage disorders of the brain and other tissues that mostly affect children and young adults. Here, we describe how we are mapping neuropathological changes in mouse and large-animal models of NCL using morphological, stereological and molecular and techniques...

We present a new set of symmetrical ray diagrams of the optical pathways in transmitted,reflected and epifluorescence light microscopes equipped with infinity-corrected optics...

Our current research project deals with the digital imaging of dried, native blood clots and we report here some pitfalls of standard digital image acquisition tools in biomedical applications and discuss the future possibilities of this emerging technique in conjunction with digital image analysis...

Differential interference contrast (DIC) light microscopy is a technique which produces impressive 3D-like images of unstained specimens. The shadowing effects of the technique are remarkable, yet often misunderstood...

Quantitative colocalization analysis is a tool to objectively estimate the degree of overlap (colocalization) of fluorescently labelled antigens in biological microscopy. It allows the drawing of unbiased conclusions about their interaction and function...