The principle of nanoscale dispensing (NADIS) in a liquid environment

Figure 1: The principle of nanoscale dispensing (NADIS) in a liquid environment. The AFM tip with integrated channels is brought into gentle contact with a soft specimen, such as a biological cell and an external pressure controller (not shown) allows a small quantity of liquid to be dispensed.

From: NADIS: A Novel AFM-based Tool for Dispensing Fluids into Single Cells

Harry Heinzelmann,1 André Meister,1 Philippe Niedermann,1 Joanna Bitterli,1 Jérôme Polesel-Maris,1 Martha Liley,1 Michael Gabi,2 Pascal Behr,2 Philipp Studer,2 Janos Vörös,2 and Tomaso Zambelli2 1. Swiss Center for Electronics and Microtechnology, CSEM SA, Neuchâtel, Switzerland. 2. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland

Microscopy and Analysis September 2009