September 2010 Americas-Asia editions Cover Picture and Story
September 2010 Americas-Asia editions Cover Picture and Story
September 2010 Americas-Asia editions Cover Story
The cover image shows fixed human colon carcinoma LoVo cells imaged with PeakForce Tapping mode on a Veeco BioScopeä Catalystä atomic force microscope. Courtesy of Frank Lafont and Joelle Warein, Pasteur Institute, Lille, France.
The images are 75 x 75 mm scans in six channels: Top left: 3D-height image, 3nm Z-scale; Top right: peak force error; Center left: Young’s modulus, DMT fit; Center right: adhesion; Bottom left: deformation; Bottom right: dissipation. For most channels, the Z-scale is in arbitrary units since the probe was not calibrated prior to the experiment.
Veeco’s new proprietary PeakForce TappingTM technique enables quantitative nanomechanical characterization at high resolution with remarkable ease of use, providing reliable results on soft, hard and even sticky samples at micrometer and nanometer scales. The channels in this image have good contrast because the glass support exhibits a very high Young’s modulus, very low deformation and high dissipation. The inner core of the cells show opposite behaviors, while the locations of the cells with underlying organelles or cytoskeleton exhibit intermediate values. The adhesion channel does not show a high contrast, most likely since capillary forces are greatly reduced under a liquid environment.
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