Carl Zeiss Microscopy: Correlative Light and Scanning Electron Microscopy
At Neuroscience, Carl Zeiss presented a unique hardware/software interface to connect light and scanning electron microscopes for correlative microscopy in the life sciences.
Geoff Lambright, 3D Specialist, BioSciences, talked to M&A Editor Dr Julian Heath about correlative microscopy from Carl Zeiss Microscopy. Scroll down to watch the video.
The “Shuttle & Find” interface enables users to recall regions of interest in fixed specimens in an electron microscope, which were previously identified in a light microscope and vice versa. The entire process takes only a few seconds. This opens up totally new dimensions in microscopy: rapid and precise overlay of light and electron microscope images, high-resolution magnification of the details, and the merger of functional and structural information.
The key elements of Shuttle & Find for correlative light and electron microscopy (CLEM) are: 1. A transferable specimen holder that enables smooth specimen transfer between the light and electron microscopes (shuttle); and 2. A software module that controls all functions of light and electron microscopes needed to identify and recall the defined region of interest (Find).
Geoff Lambright, 3D Specialist, BioSciences, talks to M&A Editor Dr Julian Heath about correlative microscopy from Carl Zeiss Microscopy: